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Mouse HPX Protein 3741

$270.00$900.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Ser24-Gln460
SKU: 3741parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q91X72

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein.

molecular weight

The protein has a predicted MW of 50 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse HPX Protein 3741

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein.
Protein names
Hemopexin
Gene names
Hpx,Hpx Hpxn
Protein family
Hemopexin family
Mass
10090Da
Function
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
Catalytic activity
BINDING 79; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="1"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000250"; BINDING 149; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="1"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000250"; BINDING 235; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="2"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000250"; BINDING 291; /ligand="heme"; /ligand_id="ChEBI:CHEBI:30413"; /ligand_label="2"; /ligand_part="Fe"; /ligand_part_id="ChEBI:CHEBI:18248"; /note="axial binding residue"; /evidence="ECO:0000250"
Subellular location
Secreted.
Tissues
Expressed by the liver and secreted in plasma.
Target Relevance information above includes information from UniProt accession: Q91X72
The UniProt Consortium

HPLC of Mouse HPX Protein
The purity of Mouse HPX is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse HPX Protein
Mouse HPX on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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