Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q9R098 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor/scatter factor. Hepatocyte growth factor/scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its receptor, MET.In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON. |
molecular weight | The protein has a predicted MW of 67.9 kDa. Due to glycosylation, the protein (pro form) migrates to 80-100 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse HGFA Protein (pro form) 3911
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Gln35-Ser653
Mouse HGFA Protein (pro form) 3911
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor/scatter factor. Hepatocyte growth factor/scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its receptor, MET.In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON. |
Protein names Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain] |
Gene names Hgfac,Hgfac |
Protein family Peptidase S1 family |
Mass 10090Da |
Function Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. |
Subellular location Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. |
Structure Heterodimer of a short chain and a long chain linked by a disulfide bond. |
Target Relevance information above includes information from UniProt accession: Q9R098 |
The UniProt Consortium |
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The purity of Mouse HGFA (pro form) is greater than 95% as determined by SEC-HPLC. |
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Mouse HGFA (pro form) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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