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Mouse G-CSF R/CD114 Protein 2954

$270.00$900.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Cys26-Asp626
SKU: 2954parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P40223

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.

molecular weight

The protein has a predicted MW of 68.47 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse G-CSF R/CD114 Protein 2954

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
Protein names
Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)
Gene names
Csf3r,Csf3r Csfgr
Protein family
Type I cytokine receptor family, Type 2 subfamily
Mass
10090Da
Function
Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.
Subellular location
Membrane; Single-pass type I membrane protein.
Tissues
Found in bone marrow.
Structure
Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969).
Post-translational modification
N-glycosylated.
Domain
Th
Target Relevance information above includes information from UniProt accession: P40223
The UniProt Consortium

ELISA with Mouse G-CSF R/CD114~-Protein
Immobilized Mouse G-CSF R, His Tag at 0.2µg/ml (100µl/Well) on the plate. Dose response curve for Human G-CSF, hFc Tag with the EC50 of 1.2ng/ml determined by ELISA.
HPLC of Mouse G-CSF R/CD114~-Protein
The purity of Mouse G-CSF R is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse G-CSF R/CD114~-Protein
Mouse G-CSF R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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