Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P40223 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal. |
molecular weight | The protein has a predicted MW of 68.47 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse G-CSF R/CD114 Protein 2954
$270.00 – $900.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Cys26-Asp626
Mouse G-CSF R/CD114 Protein 2954
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal. |
Protein names Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) |
Gene names Csf3r,Csf3r Csfgr |
Protein family Type I cytokine receptor family, Type 2 subfamily |
Mass 10090Da |
Function Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface. |
Subellular location Membrane; Single-pass type I membrane protein. |
Tissues Found in bone marrow. |
Structure Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969). |
Post-translational modification N-glycosylated. |
Domain Th |
Target Relevance information above includes information from UniProt accession: P40223 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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