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Mouse FSTL1 Protein 3001

$300.00$1,000.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Glu19-Ile306
SKU: 3001parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q62356

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Recent findings on FSTL1 in both acute coronary syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy.

molecular weight

The protein has a predicted MW of 33.57 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse FSTL1 Protein 3001

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Follistatin-like 1 (FSTL1), a secreted glycoprotein, has been shown to participate in regulating developmental processes and to be involved in states of disease and injury. Recent findings on FSTL1 in both acute coronary syndrome and heart failure emphasize its potential as a target for cardiac regenerative therapy.
Protein names
Follistatin-related protein 1 (Follistatin-like protein 1) (TGF-beta-inducible protein TSC-36)
Gene names
Fstl1,Fstl1 Frp Fstl Tsc36
Mass
10090Da
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (PubMed:19595790, PubMed:21826198). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (PubMed:20054002). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
Subellular location
Secreted .
Tissues
During central nervous system development, strongly expressed in the telencephalon, diencephalon, brainstem, limbic system and spinal cord (PubMed:19595790). Widely expressed in all organs (PubMed:21826198).
Structure
Homodimer (PubMed:31351024). Interacts with SCN10A (By similarity). Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20054002). Interacts with BMP4 (By similarity). Interacts with CD14; this interaction promotes TL4-mediated signaling cascade (By similarity).
Target Relevance information above includes information from UniProt accession: Q62356
The UniProt Consortium

HPLC of Mouse FSTL1 Protein
The purity of Mouse FSTL1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse FSTL1 Protein
Mouse FSTL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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