Mouse FOLR2 Protein 3577

$150.00 – $500.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Arg21-Ser227

SKU: 3577parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q05685
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).
molecular weight	The protein has a predicted MW of 25.3 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse FOLR2 Protein 3577

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).
Protein names Folate receptor beta (FR-beta) (Folate receptor 2) (Folate-binding protein 2)
Gene names Folr2,Folr2 Fbp2 Folbp2
Protein family Folate receptor family
Mass 10090Da
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity).
Catalytic activity BINDING 95; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P14207"; BINDING 99; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P14207"; BINDING 116..120; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P14207"; BINDING 149..154; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P14207"; BINDING 188; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P14207"
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor .
Target Relevance information above includes information from UniProt accession: Q05685
The UniProt Consortium

The purity of Mouse FOLR2 is greater than 95% as determined by SEC-HPLC.

Mouse FOLR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.