Weight | 1 lbs |
---|---|
Dimensions | 9 × 5 × 2 in |
accession | Q05685 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy). |
molecular weight | The protein has a predicted MW of 25.3 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse FOLR2 Protein 3577
$150.00 – $500.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Arg21-Ser227
Mouse FOLR2 Protein 3577
protein |
---|
Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
---|
FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy). |
Protein names Folate receptor beta (FR-beta) (Folate receptor 2) (Folate-binding protein 2) |
Gene names Folr2,Folr2 Fbp2 Folbp2 |
Protein family Folate receptor family |
Mass 10090Da |
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). |
Catalytic activity BINDING 95; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P14207"; BINDING 99; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P14207"; BINDING 116..120; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P14207"; BINDING 149..154; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P14207"; BINDING 188; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P14207" |
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor . |
Target Relevance information above includes information from UniProt accession: Q05685 |
The UniProt Consortium |
![]() |
The purity of Mouse FOLR2 is greater than 95% as determined by SEC-HPLC. |
![]() |
Mouse FOLR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
pmid | title | authors | citation |
---|---|---|---|
We haven't added any publications to our database yet. |
relevant to this product |
---|
# | ||
---|---|---|
Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information. |
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.