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Mouse FOLR1 Protein 3037

$285.00$950.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Thr25-Ser232
SKU: 3037parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P35846

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 – 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.

molecular weight

The protein has a predicted MW of 25.36 kDa. Due to glycosylation, the protein migrates to 33-43 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse FOLR1 Protein 3037

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Protein names
Folate receptor alpha (FR-alpha) (Folate receptor 1) (Folate-binding protein 1)
Gene names
Folr1,Folr1 Fbp1 Folbp1
Protein family
Folate receptor family
Mass
10090Da
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271).
Catalytic activity
BINDING 101; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P15328"; BINDING 105; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P15328"; BINDING 122..126; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P15328"; BINDING 155..160; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P15328"; BINDING 194; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250|UniProtKB:P15328"
Subellular location
Cell membrane ; Lipid-anchor, GPI-anchor. Apical cell membrane ; Lipid-anchor, GPI-anchor. Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissues
Detected in kidney proximal tubules (at protein level).
Post-translational modification
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Target Relevance information above includes information from UniProt accession: P35846
The UniProt Consortium

HPLC of Mouse FOLR1 Protein
The purity of Mouse FOLR1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse FOLR1 Protein
Mouse FOLR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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