Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | O70255 |
express system | HEK293 |
product tag | C-hFc |
purity | > 95% as determined by Tris-Bis PAGE |
background | MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. |
molecular weight | The protein has a predicted MW of 41.42 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse EVA-1/MPZL2 Protein 2998
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Pure: Yes (SDS-PAGE)
- Amino Acid Range: Val27-Leu154
Mouse EVA-1/MPZL2 Protein 2998
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. |
Protein names Myelin protein zero-like protein 2 (Epithelial V-like antigen 1) |
Gene names Mpzl2,Mpzl2 Eva Eva1 |
Protein family Myelin P0 protein family |
Mass 10090Da |
Function Mediates homophilic cell-cell adhesion. |
Subellular location Membrane ; Single-pass type I membrane protein . |
Tissues Widely expressed (PubMed:29982980, PubMed:9585423). Expressed in the cochlea, in Deiters' cells, possibly at contact sites with the basilar membrane (PubMed:29961571, PubMed:29982980). Expressed in both outer and inner auditory hair cells (PubMed:29961571, PubMed:29982980). In the stria vascularis, detected in the basal cell layer (PubMed:29961571). Not detected in thymocytes, lymphocytes, macrophage or dendritic cells (PubMed:9585423). |
Target Relevance information above includes information from UniProt accession: O70255 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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