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Mouse EREG Protein 3698

$270.00$900.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Val56-Leu101
SKU: 3698parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q61521

express system

HEK293

product tag

N-hFc

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.

molecular weight

The protein has a predicted MW of 32.7 kDa. Due to glycosylation, the protein migrates to 37-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse EREG Protein 3698

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.
Protein names
Proepiregulin [Cleaved into: Epiregulin (EPR)]
Gene names
Ereg,Ereg
Mass
10090Da
Function
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
Subellular location
[Epiregulin]: Secreted, extracellular space .; [Proepiregulin]: Cell membrane ; Single-pass type I membrane protein .
Structure
Interacts with EGFR and ERBB4.
Target Relevance information above includes information from UniProt accession: Q61521
The UniProt Consortium

HPLC of Mouse EREG Protein
The purity of Mouse EREG is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse EREG Protein
Mouse EREG on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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