Mouse CSPG5 Protein 3350

$300.00 – $1,000.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Val31-Cys423

SKU: 3350parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	AAH55736
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells.
molecular weight	The protein has a predicted MW of 42.69 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse CSPG5 Protein 3350

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation. An involvement of CALEB in the presynaptic differentiation of cerebellar GABAergic synapses and revealed a new role for CALEB in synapse elimination in Purkinje cells.
Protein names Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)
Mass 60016Da
Function May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269\|PubMed:15358134}.
Subellular location Cell membrane {ECO:0000250\|UniProtKB:Q9ERQ6}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q9ERQ6}. Synaptic cell membrane {ECO:0000250\|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q71M36}. Endoplasmic reticulum membrane {ECO:0000250\|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q71M36}. Golgi apparatus membrane {ECO:0000250\|UniProtKB:Q71M36}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q71M36}. Cell surface {ECO:0000250\|UniProtKB:Q71M36}. Secreted {ECO:0000269\|PubMed:25326458, ECO:0000269\|PubMed:37453717}. Note=In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. {ECO:0000250\|UniProtKB:Q71M36, ECO:0000250\|UniProtKB:Q9ERQ6}.
Tissues Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). Expressed in brain (at protein level) (PubMed:9950058). {ECO:0000269\|PubMed:25326458, ECO:0000269\|PubMed:37453717, ECO:0000269\|PubMed:9950058}.
Structure Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC. Interacts with MDK; this interaction is independent of the presence of chondroitin sulfate chains and promotes elongation of oligodendroglial precursor-like cells (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q9ERQ6, ECO:0000269\|PubMed:12885772, ECO:0000269\|PubMed:15358134}.
Post-translational modification N-glycosylated. {ECO:0000250}.; O-glycosylated; contains chondroitin sulfate glycans (PubMed:25326458). Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form (By similarity). The relative amount of both forms depends on tissues and tissue maturation (By similarity). {ECO:0000250\|UniProtKB:Q71M36, ECO:0000269\|PubMed:25326458}.; Phosphorylated; in intracellular and extracellular parts. {ECO:0000250}.
Target Relevance information above includes information from UniProt accession: O95196
The UniProt Consortium

Data

The purity of Mouse CSPG5 is greater than 95% as determined by SEC-HPLC.

Mouse CSPG5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.