Mouse CLEC7A Protein 3156

$240.00 – $800.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gly71-Leu244

SKU: 3156parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q6QLQ4
express system	HEK293
product tag	N-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
molecular weight	The protein has a predicted MW of 46.08 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse CLEC7A Protein 3156

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
Protein names C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
Gene names Clec7a,Clec7a Bgr Clecsf12 Dectin1
Mass 10090Da
Function Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11544516, PubMed:15213161, PubMed:17159984). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:12719479, PubMed:15731053, PubMed:16825490, PubMed:32358020). Enhances cytokine production in macrophages and dendritic cells (PubMed:15845454). Mediates production of reactive oxygen species in the cell (PubMed:12719479, PubMed:15731053, PubMed:16825490). Mediates phagocytosis of C.albicans conidia (PubMed:15729357, PubMed:16825490). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation (PubMed:10779524). Stimulates T-cell proliferation (PubMed:10779524). Induces phosphorylation of SCIMP after binding beta-glucans (PubMed:27288407).
Catalytic activity BINDING 145..152; /ligand="(1,3-beta-D-glucosyl)n"; /ligand_id="ChEBI:CHEBI:37671"; /evidence="ECO:0000305\|PubMed:17473009, ECO:0007744\|PDB:2CL8"; BINDING 156; /ligand="a divalent metal cation"; /ligand_id="ChEBI:CHEBI:60240"; /evidence="ECO:0000269\|PubMed:17473009, ECO:0007744\|PDB:2BPE, ECO:0007744\|PDB:2BPH, ECO:0007744\|PDB:2CL8"; BINDING 158; /ligand="a divalent metal cation"; /ligand_id="ChEBI:CHEBI:60240"; /evidence="ECO:0000269\|PubMed:17473009, ECO:0007744\|PDB:2BPE, ECO:0007744\|PDB:2BPH, ECO:0007744\|PDB:2CL8"; BINDING 162; /ligand="a divalent metal cation"; /ligand_id="ChEBI:CHEBI:60240"; /evidence="ECO:0000269\|PubMed:17473009, ECO:0007744\|PDB:2BPE, ECO:0007744\|PDB:2BPH, ECO:0007744\|PDB:2CL8"; BINDING 194; /ligand="(1,3-beta-D-glucosyl)n"; /ligand_id="ChEBI:CHEBI:37671"; /evidence="ECO:0000305\|PubMed:17473009, ECO:0007744\|PDB:2CL8"; BINDING 241; /ligand="a divalent metal cation"; /ligand_id="ChEBI:CHEBI:60240"; /evidence="ECO:0000269\|PubMed:17473009, ECO:0007744\|PDB:2BPE, ECO:0007744\|PDB:2BPH, ECO:0007744\|PDB:2CL8"
Subellular location Cell membrane ; Single-pass type II membrane protein. Note=Enriched on zymosan phagosomes. Enrichment does not depend on opsonization.
Tissues Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung.
Structure Homodimer (PubMed:17473009). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens (PubMed:15845454). Interacts with CD37; this interaction controls CLEC7A-mediated IL-6 production.
Post-translational modification N-glycosylated.; Phosphorylated on tyrosine residues in response to beta-glucan binding.
Target Relevance information above includes information from UniProt accession: Q6QLQ4
The UniProt Consortium

Data

The purity of Mouse CLEC7A is greater than 95% as determined by SEC-HPLC.

Mouse CLEC7A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.