Mouse CD83 Protein 3784

$195.00 – $650.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Met22-Ala134

SKU: 3784parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O88324
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). While CD83 is emerging as a promising immune modulator with therapeutic potential, some important aspects such as its ligand/s, intracellular signaling pathways and modulators of its expression are unclear.
molecular weight	The protein has a predicted MW of 39.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse CD83 Protein 3784

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). While CD83 is emerging as a promising immune modulator with therapeutic potential, some important aspects such as its ligand/s, intracellular signaling pathways and modulators of its expression are unclear.
Protein names CD83 antigen (mCD83) (CD antigen CD83)
Gene names Cd83,Cd83
Mass 21313Da
Function FUNCTION: Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8 (PubMed:27503071, PubMed:27503069). Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII (By similarity). In addition, acts as an important modulator of protective responses against acute infections (PubMed:31527313). {ECO:0000250\|UniProtKB:Q01151, ECO:0000269\|PubMed:27503069, ECO:0000269\|PubMed:27503071, ECO:0000269\|PubMed:31527313}.
Subellular location SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissues TISSUE SPECIFICITY: Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed. {ECO:0000269\|PubMed:9799334}.
Structure SUBUNIT: Monomer. Homodimer. Homotrimer. Interacts with MARCHF1; this interaction antagonizes MARCHF1-mediated MHC II and CD86 down-regulation. {ECO:0000250\|UniProtKB:Q01151}.
Target Relevance information above includes information from UniProt accession: O88324
The UniProt Consortium

Data

The purity of Mouse CD83 is greater than 95% as determined by SEC-HPLC.

Mouse CD83 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.