Mouse CD39/ENTPD1 Protein 3044

$450.00 – $1,500.00

Summary

Expression: HEK293
Active: Yes (catalytic)
Amino Acid Range: Thr38-Ile478

SKU: 3044parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P55772
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues.CD39 is involved in the processes of thromboregulation and vascular inflammation. The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases .
molecular weight	The protein has a predicted MW of 50.72 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse CD39/ENTPD1 Protein 3044

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues.CD39 is involved in the processes of thromboregulation and vascular inflammation. The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases .
Protein names Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39)
Gene names Entpd1,Entpd1 Cd39
Protein family GDA1/CD39 NTPase family
Mass 10090Da
Function Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Subellular location Membrane ; Multi-pass membrane protein. Membrane, caveola .
Structure Homodimer; disulfide-linked.
Post-translational modification N-glycosylated.; The N-terminus is blocked.; Palmitoylated on Cys-13; which is required for caveola targeting.
Target Relevance information above includes information from UniProt accession: P55772
The UniProt Consortium

Data

Activity assay with Mouse CD39/ENTPD1 Protein

Measured by its ability to hydrolyze the 5'-phosphate groups from the substrate adenosine-5'-triphosphate (ATP). The specific activity is >18,000 pmol/min/µg.

The purity of Mouse CD39 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse CD39/ENTPD1 Protein

Mouse CD39 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.