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Mouse CD21 Protein 3334

$270.00$900.00

Summary

  • Expression: HEK293
  • Pure: Yes (SDS-PAGE)
  • Amino Acid Range: Ile12-Trp963
SKU: 3334parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P19070

express system

HEK293

product tag

C-His

purity

> 90% as determined by Tris-Bis PAGE

background

A natural soluble form of CD21 that is cleaved from lymphocyte membrane CD21 circulates in normal human serum. Soluble CD21 retains the capacity to bind iC3b and CD23, the known ligands of membrane CD21. In a similar fashion to IgE complexes, another ligand of CD23, the soluble CD21 was shown to efficiently trigger CD23-signalling pathways in human monocytes.

molecular weight

The protein has a predicted MW of 106.03 kDa. Due to glycosylation, the protein migrates to 130-160 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse CD21 Protein 3334

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
A natural soluble form of CD21 that is cleaved from lymphocyte membrane CD21 circulates in normal human serum. Soluble CD21 retains the capacity to bind iC3b and CD23, the known ligands of membrane CD21. In a similar fashion to IgE complexes, another ligand of CD23, the soluble CD21 was shown to efficiently trigger CD23-signalling pathways in human monocytes.
Protein names
Complement receptor type 2 (Cr2) (Complement C3d receptor) (CD antigen CD21)
Gene names
Cr2,Cr2
Protein family
Receptors of complement activation (RCA) family
Mass
10090Da
Function
Receptor for complement C3d and for HNRNPU. Participates in B lymphocytes activation.
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
B-lymphocytes.
Structure
Interacts (via Sushi domain 1 and 2) with C3. Interacts with CD19. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts (via Sushi domain 1 and 2) with FCER2 (via the C-terminus).
Target Relevance information above includes information from UniProt accession: P19070
The UniProt Consortium

Data

SDS-PAGE gel of Mouse CD21 Protein
Mouse CD21 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

relevant to this product

Documents

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