SPR with Mouse BCMA/TNFRSF17 Protein 4492

Mouse BCMA/TNFRSF17 Protein 4492

$345.00 – $1,150.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Met1-Thr49

SKU: 4492parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O88472
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE
background	B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
molecular weight	The protein has a predicted MW of 8.5 kDa. Due to glycosylation, the protein migrates to 12-16 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse BCMA/TNFRSF17 Protein 4492

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
Protein names Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Gene names Tnfrsf17,Tnfrsf17 Bcm Bcma
Mass 10090Da
Function Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity).
Subellular location Membrane ; Single-pass type III membrane protein .
Tissues Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.
Structure Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
Target Relevance information above includes information from UniProt accession: O88472
The UniProt Consortium

Data

Human BAFF, hFc Tag captured on CM5 Chip via Protein A can bind Mouse BCMA, His-Avi Tag with an affinity constant of 5.83 µM as determined in SPR assay (Biacore T200).

Immobilized Mouse BCMA, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Mouse APRIL, hFc Tag with the EC50 of 93.9ng/ml determined by ELISA (QC Test).

SDS-PAGE gel of Mouse BCMA/TNFRSF17 Protein

Mouse BCMA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.