Mouse B2M/beta 2-Microglobulin Protein 3830

$210.00 – $700.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Ile21-Met119

available size

Clear

SKU: 3830parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P01887
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
molecular weight	The protein has a predicted MW of 38.4 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse B2M/beta 2-Microglobulin Protein 3830

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors.
Protein names Beta-2-microglobulin
Gene names B2m,B2m
Protein family Beta-2-microglobulin family
Mass 13779Da
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subellular location Secreted.
Structure Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Forms a heterotrimer with MR1 and a metabolite antigen.
Target Relevance information above includes information from UniProt accession: P01887
The UniProt Consortium

Data

HPLC of Mouse B2M/beta 2-Microglobulin Protein

The purity of Mouse B2M is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse B2M/beta 2-Microglobulin Protein

Mouse B2M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.