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MDA (malondialdehyde) modified Apolipoprotein B (ApoB) antigen 1015

$578.00 – $926.00

Antibody summary

  • Rabbit polyclonal to MDA ApoB
  • Suitable for: WB,IP
  • Reacts with: Hu MDA ApoB
  • Isotype:
  • 0.5mg, 1 mg
SKU: 1015parent Categories: , , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
concentration

1 mg/mL

applications

IP, WB

reactivity

MDA ApoB, protein

available sizes

0.5 mg, 1 mg

mdaapob antigen 1015

kit
Storage
Store at -20°C
Form
liquid
(APOB)
target relevance
Organism
Homo sapiens (Human)
Protein names
Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
Gene names
APOB
Mass
515545Da
Function
FUNCTION: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subellular location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22580899}. Secreted {ECO:0000269|PubMed:22580899, ECO:0000269|PubMed:26224785}. Lipid droplet {ECO:0000269|PubMed:28183703}.
Structure and strains
SUBUNIT: Interacts with PCSK9 (PubMed:22580899). Interacts with MTTP (PubMed:26224785, PubMed:27206948). Interacts with AUP1 (PubMed:28183703). Interacts with CIDEB (By similarity). {ECO:0000250|UniProtKB:E9Q414, ECO:0000269|PubMed:22580899, ECO:0000269|PubMed:26224785, ECO:0000269|PubMed:27206948, ECO:0000269|PubMed:28183703}.
Post-translational modification
PTM: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. {ECO:0000269|PubMed:10679026}.
Disease
DISEASE: Hypobetalipoproteinemia, familial, 1 (FHBL1) [MIM:615558]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. {ECO:0000269|PubMed:12551903, ECO:0000269|PubMed:21981844, ECO:0000269|PubMed:27206948}. Note=The disease is caused by variants affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844). {ECO:0000269|PubMed:21981844}.; DISEASE: Hypercholesterolemia, familial, 2 (FHCL2) [MIM:144010]: A form of hypercholesterolemia, a disorder of lipoprotein metabolism characterized by elevated serum low-density lipoprotein (LDL) cholesterol levels, which result in excess deposition of cholesterol in tissues and leads to xanthelasma, xanthomas, accelerated atherosclerosis and increased risk of premature coronary heart disease. FHCL2 inheritance is autosomal dominant. {ECO:0000269|PubMed:21382890, ECO:0000269|PubMed:2563166, ECO:0000269|PubMed:7883971, ECO:0000269|PubMed:9259199}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.
Target Relevance information above includes information from UniProt accession : P04114
The UniProt Consortium

Data

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Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

relevant to this product
Western blot

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