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Human XPNPEP2 Protein 2718

$345.00$1,150.00

Summary

  • Expression: HEK293
  • Active: Yes (catalytic)
  • Amino Acid Range: His22-Ala649
SKU: 2718parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O43895

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.

molecular weight

The protein has a predicted MW of 71.83 kDa. Due to glycosylation, the protein migrates to 73-83 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human XPNPEP2 Protein 2718

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.
Protein names
Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)
Gene names
XPNPEP2,XPNPEP2
Protein family
Peptidase M24B family
Mass
9606Da
Function
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.
Catalytic activity
BINDING 116; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 430; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 450; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 461; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 461; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 524; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 524; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 533; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 555; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 555; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 569; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 569; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"
Subellular location
Cell membrane ; Lipid-anchor, GPI-anchor .
Tissues
Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary.
Structure
Homotrimer.
Post-translational modification
N-glycosylated.
Target Relevance information above includes information from UniProt accession: O43895
The UniProt Consortium

Data

Activity assay with Human XPNPEP2 Protein
Measured by its ability to cleave the fluorogenic peptide substrate, H-Lys(2-Aminobenzoyl)-Pro-Pro-p-Nitroanilide (K(Abz)PP-pNA). The specific activity is > 300 pmol/min/µg.
HPLC of Human XPNPEP2 Protein
The purity of Human XPNPEP2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human XPNPEP2 Protein
Human XPNPEP2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

relevant to this product

Documents

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