Human VSTM5 Protein 3632

Human VSTM5 Protein 3632

protein
Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
V-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced the complexity of dendritic structures, as well as the number of dendritic filopodia. Vstm5 also regulates neuronal morphology by promoting dendritic protrusions that later develop into dendritic spines.
Protein names V-set and transmembrane domain-containing protein 5
Gene names VSTM5,VSTM5 C11orf90
Mass 9606Da
Function Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.
Subellular location Cell membrane ; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, axon .
Structure Can homooligomerize through cis interactions within the same cell membrane.
Post-translational modification N-glycosylated.
Target Relevance information above includes information from UniProt accession: A8MXK1
The UniProt Consortium