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Human TROP-2/TACSTD2 Protein 5182

$165.00$550.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: His27-Thr274
SKU: 5182parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P09758

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

background

Trop-2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

molecular weight

The protein has a predicted MW of 28.9 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1 EU per μg by the LAL method.

Human TROP-2/TACSTD2 Protein 5182

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Trop-2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Protein names
Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)
Gene names
TACSTD2,TACSTD2 GA733-1 M1S1 TROP2
Protein family
EPCAM family
Mass
9606Da
Function
FUNCTION: May function as a growth factor receptor.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Tissues
TISSUE SPECIFICITY: Placenta, pancreatic carcinoma cell lines.
Post-translational modification
PTM: The N-terminus is blocked.
Target Relevance information above includes information from UniProt accession : P09758
The UniProt Consortium

Data

ELISA with Human TROP-2/TACSTD2 Protein
Immobilized Human TROP-2, His Tag at 0.5 µg/ml (100 µl/Well). Dose response curve for Anti-TROP-2 Antibody, hFc Tag with the EC50 of 7.1 ng/ml determined by ELISA (QC Test).
ELISA with Human TROP-2/TACSTD2 Protein
Immobilized Human TROP-2, His Tag at 0.5 µg/ml (100 µl/Well). Dose response curve for Anti-TROP-2 Antibody, hFc Tag with the EC50 of 7.1 ng/ml/7.2 ng/ml/7.2 ng/ml determined by ELISA.
HPLC of Human TROP-2/TACSTD2 Protein
The purity of Human TROP-2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human TROP-2/TACSTD2 Protein
Human TROP-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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