ELISA with Human TROP-2/TACSTD2 Protein 4838

Human TROP-2/TACSTD2 Protein 4838

$180.00 – $600.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: His27-Thr274

SKU: 4838parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P09758
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Trop-2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene.Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
molecular weight	The protein has a predicted MW of 54.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human TROP-2/TACSTD2 Protein 4838

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Trop-2,also known as epithelial glycoprotein-1 antigen (EGP-1),is a protein that in humans is encoded by the TACSTD2 gene.Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Protein names Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)
Protein family EPCAM family
Mass 35709Da
Function May function as a growth factor receptor.
Subellular location Membrane; Single-pass type I membrane protein.
Tissues Placenta, pancreatic carcinoma cell lines.
Post-translational modification The N-terminus is blocked.
Target Relevance information above includes information from UniProt accession: P09758
The UniProt Consortium

Data

Immobilized Human TROP-2, hFc Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Anti-TROP-2 Antibody, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA.

The purity of Human TROP-2 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human TROP-2/TACSTD2 Protein

Human TROP-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.