Human THSD7A Protein 3304

$450.00 – $1,500.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Ala48–Trp1607

SKU: 3304parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9UPZ6
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Thrombospondin type I domain-containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A-AB) represents a promising biomarker for diagnosis of IMN.
molecular weight	The protein has a predicted MW of 176.22 kDa. Due to glycosylation, the protein migrates to 180-240 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human THSD7A Protein 3304

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Thrombospondin type I domain-containing 7A (THSD7A), is a specific autoantigen of adult idiopathic membranous nephropathy (IMN), whose circulating antibody (THSD7A-AB) represents a promising biomarker for diagnosis of IMN.
Protein names Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]
Gene names THSD7A,THSD7A KIAA0960
Mass 185363Da
Function FUNCTION: [Thrombospondin type-1 domain-containing protein 7A]: Plays a role in actin cytoskeleton rearrangement. {ECO:0000269\|PubMed:27214550}.; FUNCTION: [Thrombospondin type-1 domain-containing protein 7A, soluble form]: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. {ECO:0000269\|PubMed:22194972}.
Subellular location SUBCELLULAR LOCATION: [Thrombospondin type-1 domain-containing protein 7A]: Cell membrane {ECO:0000269\|PubMed:22194972, ECO:0000269\|PubMed:25394321, ECO:0000269\|PubMed:27214550}; Single-pass type I membrane protein {ECO:0000269\|PubMed:22194972}. Cell projection {ECO:0000250\|UniProtKB:Q69ZU6}. Note=Detected on podocyte foot processes. {ECO:0000250\|UniProtKB:Q69ZU6}.; SUBCELLULAR LOCATION: [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted {ECO:0000269\|PubMed:22194972}. Note=Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. {ECO:0000269\|PubMed:22194972}.
Tissues TISSUE SPECIFICITY: Detected on kidney podocytes along the glomerular capillary wall (at protein level). {ECO:0000269\|PubMed:25394321}.
Post-translational modification PTM: Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. {ECO:0000269\|PubMed:22194972}.; PTM: Extensively N-glycosylated. {ECO:0000269\|PubMed:22194972, ECO:0000269\|PubMed:25394321, ECO:0000269\|PubMed:29555830}.
Domain DOMAIN: Sequence analysis combined with the expression of constructs corresponding each to two or three adjacent TSP type-1 domains suggests the presence of 21 TSP type-1 domains; not all of these are detected by standard bioinformatic tools. {ECO:0000303\|PubMed:29555830, ECO:0000303\|PubMed:30520531}.
Target Relevance information above includes information from UniProt accession: Q9UPZ6
The UniProt Consortium

Data

The purity of Human THSD7A is greater than 95% as determined by SEC-HPLC.

Human THSD7A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.