Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) IgG
species reactivity
Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2)
applications
Lateral flow (dipstick)
assay type
Indirect & qualitative
available sizes
2x 20 test kits
Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) IgG Lateral flow dipstick kit 5272
kit
Assay type Sandwich assay, lateral flow (dipstick)
Research area Infectious Disease
Sample type Serum, plasma, whole blood
Components
10X Wash Buffer
100 mL
TMB Substrate
40 mL
Milk Powder
5 g
Instructions for Use
1 Each
Evaluation Form
1 Each
Test Strips
2 kits of [2 Vials x 10 Each]
Anti-Human IgG Conjugate
500 µL
Positive Control
140 µL
Negative Control
140 µL
Storage Store at 2-8°C.
Additional information Mikrogen recomLine HTLV-1 & HTLV-2 IgG Test
The Mikrogen recomLine HTLV-1 & HTLV-2 IgG Test is a serological, qualitative line immunoassay for the detection of IgG antibodies against HTLV in human serum or plasma. This test allows differentiation between virus types 1 and 2, making it ideal for confirming screening results.
Advantages
Excellent typing of HTLV-1 and HTLV-2 on one test strip.
100% sensitivity.
Easy and clear interpretation, featuring easy-to-read banding patterns.
Partial and full automation, software-based evaluation (recomScan), and integration with the laboratory information system are possible.
Highest sensitivity and specificity due to the use of recombinant HTLV antigens.
Bands
Antigen
Gene Area
Function/Localization
gp46-1 / gp46-2
ENV HTLV-1 / ENV HTLV-2
External glycoprotein, component of the viral envelope of HTLV
gp21
ENV (Type independent)
Component of the viral envelope of HTLV
p24-1 / p24-2
GAG HTLV-1 / GAG HTLV-2
Capsid protein
p19-1 / p19-2
GAG HTLV-1 / GAG HTLV-2
Matrix protein
target relevance
human antibody anti-Human T-lymphotropic Virus
Human T-lymphotropic Virus
Description Retrovirus that causes adult T-cell leukemia/lymphoma and HTLV-associated neurological disease
Structure Human T-lymphotropic viruses (HTLVs) are enveloped, positive-sense, single-stranded RNA retroviruses belonging to the genus Deltaretrovirus within the family Retroviridae. Following infection, the viral RNA genome is reverse transcribed into DNA and integrated into the host genome as a provirus, allowing lifelong persistence. HTLV-1 is the most clinically significant member of the group and is associated with adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-2 has been linked to certain neurological disorders but is generally considered less pathogenic. Transmission occurs through sexual contact, blood transfusion, needle sharing, organ transplantation, and from mother to child, particularly through breastfeeding. The virus primarily infects CD4-positive T lymphocytes and establishes chronic infection that may remain asymptomatic for decades.
Diagnosis The diagnosis of Human T-lymphotropic virus infection is performed through serological and molecular methods. Screening is commonly performed using ELISA or chemiluminescent immunoassays that detect antibodies against HTLV antigens. Reactive samples are typically confirmed using immunoblot, line immunoassay, or nucleic acid amplification techniques. Polymerase chain reaction (PCR) assays may be used to detect proviral DNA and determine viral subtype, as well as to monitor proviral load in infected individuals. Because many infected persons remain asymptomatic throughout life, laboratory testing is essential for identifying infection, screening blood donors, and preventing transmission.
Symptoms Most individuals infected with Human T-lymphotropic virus remain asymptomatic for life. In a minority of infected individuals, particularly those infected with HTLV-1, severe disease may develop after a latency period of several decades. Adult T-cell leukemia/lymphoma may present with lymphadenopathy, skin lesions, hypercalcemia, hepatosplenomegaly, recurrent infections, and progressive malignancy of T lymphocytes. HTLV-1-associated myelopathy/tropical spastic paraparesis is a chronic inflammatory neurological disorder characterized by progressive weakness and stiffness of the legs, gait disturbances, bladder dysfunction, and sensory abnormalities. Additional manifestations may include uveitis, infective dermatitis, and increased susceptibility to certain opportunistic infections. Disease progression is often slow but can result in significant disability and reduced quality of life.
Data
FAQ & Publications
Frequently Asked Questions
What types of samples are compatible with the Human T-lymphotropic virus type 1 and 2 IgG Lateral flow dipstick kit 5272?
This kit is compatible with serum, plasma, and whole blood samples for the detection of IgG antibodies against HTLV-1 and HTLV-2.
How should the Human T-lymphotropic virus type 1 and 2 IgG Lateral flow dipstick kit 5272 be stored to maintain stability?
The kit should be stored at 2-8°C to ensure proper stability and performance.
Publications
pmid
title
authors
citation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
Protocols
relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU). 5272 protocol
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