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Human SOST/Sclerostin Protein 4503

$300.00$1,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln24-Tyr213
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q9BQB4

express system

HEK293

product tag

N-His-Avi

purity

> 95% as determined by Tris-Bis PAGE

background

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

molecular weight

The protein has a predicted MW of 24.2 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human SOST/Sclerostin Protein 4503

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Protein names
Sclerostin
Gene names
SOST,SOST UNQ2976/PRO7455/PRO7476
Protein family
Sclerostin family
Mass
9606Da
Function
FUNCTION: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. {ECO:0000269|PubMed:15908424}.
Subellular location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Tissues
TISSUE SPECIFICITY: Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level). {ECO:0000269|PubMed:20551380}.
Structure
SUBUNIT: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6. {ECO:0000269|PubMed:15908424, ECO:0000269|PubMed:21471202}.
Target Relevance information above includes information from UniProt accession : Q9BQB4
The UniProt Consortium

Data

ELISA with Human SOST/Sclerostin Protein
Immobilized Human SOST, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.3ng/ml determined by ELISA.
SDS-PAGE gel of Human SOST/Sclerostin Protein
Human SOST on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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