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Human SIRP alpha V4 Protein 4891

$270.00$900.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Glu31-Arg370(E33G, L44S, T50S, T52I, R54H)
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P78324 variant 4

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.

molecular weight

The protein has a predicted MW of 39.8 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human SIRP alpha V4 Protein 4891

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
No information
target relevance

Data

ELISA with Human SIRP alpha V4 Protein
Immobilized Human SIRP alpha V4, His Tag at 1µg/ml (100µl/Well). Dose response curve for Human CD47, hFc Tag with the EC50 of 44.3ng/ml determined by ELISA.
HPLC of Human SIRP alpha V4 Protein
The purity of Human SIRP alpha V4 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human SIRP alpha V4 Protein
Human SIRP alpha V4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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