Human SARS-CoV-2 IgG Lateral flow dipstick kit 7374

$487.00

Summary

Mikrogen diagnostik lateral flow device (dipstick) for research use (RUO)
Human SARS-CoV-2 IgG Lateral flow dipstick kit 7374
Suitable for IgG detection
Ready-to-use
20 tests

SKU: 7374 Category: Mikrogen kits Tags: IgG, Lateral Flow Dipsticks, SARS-CoV-2

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Human SARS-CoV-2 IgG
species reactivity	Human SARS-CoV-2
applications	Lateral flow (dipstick)
assay type	Indirect & qualitative
available sizes	20 test kits

Human SARS-CoV-2 IgG Lateral flow dipstick kit 7374

Assay type
Sandwich assay, lateral flow (dipstick)

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instructions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 kits of [2 Vials x 10 Each]
Anti-Human IgG Conjugate	500 µL
Positive Control	140 µL
Negative Control	140 µL

Storage
Store at 2-8°C.

Additional information
Mikrogen recomLine SARS-CoV-2 IgG [Avidity] Test

In commercial screening tests for antibody detection, the nucleocapsid protein (NP) and/or the spike protein (S) or corresponding subunits are usually used as immunodominant antigens. The Mikrogen recomLine SARS-CoV-2 IgG [avidity] line immunoassay combines these diagnostic markers and allows the identification of specific antibodies against the individual antigens. In addition, reactivities against the seasonal coronaviruses (HCoV) are detected.

The test allows the assessment of the adaptive humoral immune response to SARS-CoV-2 after infection and/or vaccination. An added benefit is that this test system determines the quality of the antibodies when avidity measurement is used.

Advantages

Detection of antibodies against SARS-CoV-2 after survived infection and/or vaccination.
Avidity determination of SARS-CoV-2 specific IgG antibodies provides additional information about the quality of the antibodies.
Additional information through the detection of antibodies against seasonal coronaviruses (HCoV).
Suitability as a screening and confirmatory test for the detection of IgG.
Easy and clear interpretation, featuring easy-to-read banding patterns.
Partial and full automation, software-based evaluation (recomScan), and integration with the laboratory information system are possible.
Highest sensitivity and specificity due to the use of different, recombinant SARS-CoV-2 specific antigens.

Bands

Pathogen	Antigen	Description
SARS-CoV-2	NP	Nucleocapsid - antigen with the strongest immunogenicity among the coronaviruses. As a structural protein, it primarily serves to package viral genetic information and also fulfills regulatory functions.
SARS-CoV-2	RBD	Units of the spike surface protein - main target antigen for neutralizing antibodies. The S1 subunits with integrated receptor binding domain (RBD) are responsible for binding to the host cell.
SARS-CoV-2	S1	Spike protein subunit responsible for binding to the host cell.
Seasonal coronaviruses HCoV (229E, NL63, OC43, HKU1)	NP	Nucleocapsid - analogous to the nucleocapsid of SARS-CoV-2, found in seasonal human pathogenic ?- and ?-coronaviruses (229E, NL63 and OC43, HKU1, respectively).

target relevance

human antibody anti-SARS-CoV-2

SARS-CoV-2

Description
Virus that causes Coronavirus Disease 2019 (COVID-19)

Structure
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus belonging to the genus Betacoronavirus within the family Coronaviridae. The viral genome is approximately 30 kilobases in length, making it one of the largest known RNA virus genomes. The virus is characterized by prominent spike (S) glycoproteins projecting from the viral envelope, which mediate attachment to host cells through the angiotensin-converting enzyme 2 (ACE2) receptor. SARS-CoV-2 primarily infects epithelial cells of the respiratory tract but can affect multiple organ systems including the cardiovascular, gastrointestinal, neurological, and renal systems. Since its emergence in late 2019, the virus has evolved into numerous variants through genetic mutation and selection, resulting in changes in transmissibility, immune evasion, and disease severity.

Diagnosis
The diagnosis of SARS-CoV-2 infection is performed through the detection of viral RNA, viral antigens, or virus-specific antibodies. Reverse transcription polymerase chain reaction (RT-PCR) remains the gold standard for the detection of viral RNA in respiratory specimens and provides high sensitivity and specificity. Rapid antigen tests are widely used for point-of-care diagnosis and screening, although they are generally less sensitive than molecular methods. Serological assays, including ELISA-based tests, may be used to detect antibodies generated following infection or vaccination and are useful for epidemiological studies and assessment of immune responses. Laboratory findings in severe cases may include elevated inflammatory markers, lymphopenia, and abnormalities in coagulation parameters.

Symptoms
SARS-CoV-2 is primarily transmitted through respiratory droplets, aerosols, and direct contact with contaminated secretions. Following an incubation period of approximately two to fourteen days, infected individuals may develop fever, cough, fatigue, headache, sore throat, nasal congestion, myalgia, and loss of taste or smell. Additional manifestations may include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Disease severity ranges from asymptomatic infection to severe pneumonia, acute respiratory distress syndrome (ARDS), multi-organ failure, and death. Elderly individuals and patients with underlying medical conditions are at increased risk of severe disease. Persistent symptoms following acute infection, commonly referred to as post-COVID condition or Long COVID, may affect multiple organ systems and persist for weeks or months after the initial illness.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Human SARS-CoV-2 IgG Lateral Flow Dipstick Kit 7374?

The kit is suitable for use with serum, plasma, and whole blood samples for the detection of human SARS-CoV-2 IgG antibodies.

How should the Human SARS-CoV-2 IgG Lateral Flow Dipstick Kit 7374 be stored to maintain stability?

The kit components should be stored at a temperature of 2-8°C to ensure optimal stability and performance.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU).