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Human PRL-3/PTP4A3 Protein 2936

$270.00$900.00

Summary

  • Expression: E.coli
  • Active: Yes (catalytic)
  • Amino Acid Range: Met1-Cys170
SKU: 2936parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O75365

express system

E.coli

product tag

N-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.

molecular weight

The protein has a predicted MW of 20.29 kDa same as Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human PRL-3/PTP4A3 Protein 2936

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.
Protein names
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)
Gene names
PTP4A3,PTP4A3 PRL3
Protein family
Protein-tyrosine phosphatase family
Mass
9606Da
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Subellular location
Cell membrane. Early endosome .
Tissues
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Structure
Interacts with tubulin.
Post-translational modification
Farnesylated. Farnesylation is required for membrane targeting (By similarity).
Target Relevance information above includes information from UniProt accession: O75365
The UniProt Consortium

Data

Activity assay with Human PRL-3/PTP4A3 Protein
Measured by its ability to cleave a substrate. p-Nitrophenvl phosphate (pNPP). The specific activity is > 0.5 pmol/min/µg.
HPLC of Human PRL-3/PTP4A3 Protein
The purity of Human PRL-3 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human PRL-3/PTP4A3 Protein
Human PRL-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product

Documents

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