Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q12974 |
express system | E.coli |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators.PRL-2 is a member of PTP family and has an important function in controlling cell growth. |
molecular weight | The protein has a predicted MW of 19.89 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human PRL-2/PTP4A2 Protein 2941
$270.00 – $900.00
Summary
- Expression: E.coli
- Active: Yes (catalytic)
- Amino Acid Range: Met1-Cys164
Human PRL-2/PTP4A2 Protein 2941
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators.PRL-2 is a member of PTP family and has an important function in controlling cell growth. |
Protein names Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) |
Gene names PTP4A2,PTP4A2 PRL2 PTPCAAX2 BM-008 |
Protein family Protein-tyrosine phosphatase family |
Mass 9606Da |
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. |
Subellular location Cell membrane. Early endosome. Cytoplasm. |
Tissues Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. |
Structure In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB. |
Post-translational modification Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol. |
Target Relevance information above includes information from UniProt accession: Q12974 |
The UniProt Consortium |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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