Human PRL-2/PTP4A2 Protein 2941

$270.00 – $900.00

Summary

Expression: E.coli
Active: Yes (catalytic)
Amino Acid Range: Met1-Cys164

SKU: 2941parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q12974
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators.PRL-2 is a member of PTP family and has an important function in controlling cell growth.
molecular weight	The protein has a predicted MW of 19.89 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human PRL-2/PTP4A2 Protein 2941

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators.PRL-2 is a member of PTP family and has an important function in controlling cell growth.
Protein names Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)
Gene names PTP4A2,PTP4A2 PRL2 PTPCAAX2 BM-008
Protein family Protein-tyrosine phosphatase family
Mass 9606Da
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Subellular location Cell membrane. Early endosome. Cytoplasm.
Tissues Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
Structure In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
Post-translational modification Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
Target Relevance information above includes information from UniProt accession: Q12974
The UniProt Consortium

Data

Activity assay with Human PRL-2/PTP4A2 Protein

Measured by its ability to cleave a substrate. p-Nitrophenvl phosphate (pNPP). The specific activity is > 0.5 pmol/min/µg.

The purity of Human PRL-2 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human PRL-2/PTP4A2 Protein

Human PRL-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.