Skip to content

Human PBK/TOPK Protein 2350

$315.00$1,050.00

Summary

  • Expression: Baculovirus-Insect Cells
  • Pure: Yes (SDS-PAGE)
  • Amino Acid Range: Met1-Val322
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q96KB5

express system

Baculovirus-Insect Cells

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE

background

T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1.

molecular weight

The protein has a predicted MW of 37.61 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human PBK/TOPK Protein 2350

Data

SDS-PAGE gel of Human PBK/TOPK Protein
Human PBK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product

Documents

#
No results found

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.