Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P00439 |
express system | Baculovirus-Insect Cells |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism. |
molecular weight | The protein has a predicted MW of 52.82 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human PAH (D415N) Protein 2333
$300.00 – $1,000.00
Summary
- Expression: Baculovirus-Insect Cells
- Pure: Yes (HPLC)
- Amino Acid Range: Met1-Lys452 (D415N)
Human PAH (D415N) Protein 2333
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism. |
Protein names Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) |
Gene names PAH,PAH |
Protein family Biopterin-dependent aromatic amino acid hydroxylase family |
Mass 9606Da |
Function Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. |
Catalytic activity BINDING 285; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250|UniProtKB:P04176"; BINDING 290; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250|UniProtKB:P04176"; BINDING 330; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250|UniProtKB:P04176" |
Pathway PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. |
Structure Homodimer and homotetramer. |
Post-translational modification Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine. |
Target Relevance information above includes information from UniProt accession: P00439 |
The UniProt Consortium |
Data
The purity of Human PAH (D415N) is greater than 95% as determined by SEC-HPLC. |
Human PAH (D415N) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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