Human PAH (D415N) Protein 2333

$300.00 – $1,000.00

Summary

Expression: Baculovirus-Insect Cells
Pure: Yes (HPLC)
Amino Acid Range: Met1-Lys452 (D415N)

SKU: 2333parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P00439
express system	Baculovirus-Insect Cells
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
molecular weight	The protein has a predicted MW of 52.82 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human PAH (D415N) Protein 2333

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
Protein names Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)
Gene names PAH,PAH
Protein family Biopterin-dependent aromatic amino acid hydroxylase family
Mass 9606Da
Function Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.
Catalytic activity BINDING 285; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250\|UniProtKB:P04176"; BINDING 290; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250\|UniProtKB:P04176"; BINDING 330; /ligand="Fe cation"; /ligand_id="ChEBI:CHEBI:24875"; /evidence="ECO:0000250\|UniProtKB:P04176"
Pathway PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.
Structure Homodimer and homotetramer.
Post-translational modification Phosphorylation at Ser-16 increases basal activity and facilitates activation by the substrate phenylalanine.
Target Relevance information above includes information from UniProt accession: P00439
The UniProt Consortium

Data

The purity of Human PAH (D415N) is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human PAH (D415N) Protein

Human PAH (D415N) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.