Human MOG/Myelin Oligodendrocyte Glycoprotein Protein 3463

$270.00 – $900.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gly30-Gly154

available size

Clear

SKU: 3463parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q16653
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM).
molecular weight	The protein has a predicted MW of 15.4 kDa. Due to glycosylation, the protein migrates to 20-23 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human MOG/Myelin Oligodendrocyte Glycoprotein Protein 3463

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM).
Protein names
Myelin-oligodendrocyte glycoprotein
Gene names
MOG,MOG
Protein family
Immunoglobulin superfamily, BTN/MOG family
Mass
9606Da
Function
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.; (Microbial infection) Acts as a receptor for rubella virus.
Subellular location
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 5]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 6]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 7]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 8]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 9]: Cell membrane ; Single-pass type I membrane protein .
Tissues
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Structure
Homodimer (By similarity). May form heterodimers between the different isoforms (By similarity).; (Microbial infection) Interacts with rubella virus E2 glycoprotein.
Target Relevance information above includes information from UniProt accession: Q16653
The UniProt Consortium

Data

HPLC of Human MOG/Myelin Oligodendrocyte Glycoprotein Protein

The purity of Human MOG is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human MOG/Myelin Oligodendrocyte Glycoprotein Protein

Human MOG on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.