Human LY6G6D Protein 2306

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Asn20-Ser104

SKU: 2306parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O95868
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
molecular weight	The protein has a predicted MW of 10.20 kDa. Due to glycosylation, the protein migrates to 13-15 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human LY6G6D Protein 2306

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Protein names Lymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein)
Gene names LY6G6D,LY6G6D C6orf23 G6D MEGT1 NG25
Mass 9606Da
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor. Cell projection, filopodium .
Tissues Expressed in the adult lung, and in fetal liver, lung, kidney, brain and spleen.
Structure Homodimer.
Post-translational modification O-glycosylated.
Target Relevance information above includes information from UniProt accession: O95868
The UniProt Consortium

Data

Immobilized Human LY6G6D, His Tag at 0.2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA.

The purity of Human LY6G6D is greater than 95% as determined by SEC-HPLC.

Human LY6G6D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.