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Human KIR2DL1 Protein 4655

$270.00$900.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: His22-Arg242
SKU: 4655parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P43626

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

KIR2DL1 (2DL1, formerly NKAT1, designated CD158a) is a 348 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig-like receptor (KIR) family.KIR2DL1 is a receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.

molecular weight

The protein has a predicted MW of 27.1 kDa. Due to glycosylation, the protein migrates to 40-52 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human KIR2DL1 Protein 4655

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
KIR2DL1 (2DL1, formerly NKAT1, designated CD158a) is a 348 amino acid (aa) type I transmembrane glycoprotein that belongs to the human killer cell Ig-like receptor (KIR) family.KIR2DL1 is a receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.
Protein names
Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a)
Gene names
KIR2DL1,KIR2DL1 CD158A NKAT1
Protein family
Immunoglobulin superfamily
Mass
9606Da
Function
FUNCTION: Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:18604210}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18624290}; Single-pass type I membrane protein.
Tissues
TISSUE SPECIFICITY: Expressed by NK cells. {ECO:0000269|PubMed:9430221}.
Structure
SUBUNIT: Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. {ECO:0000269|PubMed:18604210}.
Target Relevance information above includes information from UniProt accession : P43626
The UniProt Consortium

Data

HPLC of Human KIR2DL1 Protein
The purity of Human KIR2DL1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human KIR2DL1 Protein
Human KIR2DL1 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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