Human Jagged 1/JAG1 Protein 2591

$1,000.00

Summary

Expression: HEK293
Pure: Yes (SDS-PAGE)
Amino Acid Range: Gln34-Ser1046

SKU: 2591parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P78504
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.
molecular weight	The protein has a predicted MW of 111.56 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Jagged 1/JAG1 Protein 2591

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.
Protein names Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Gene names JAG1,JAG1 JAGL1
Mass 9606Da
Function Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Subellular location Membrane; Single-pass type I membrane protein. Cell membrane .
Tissues Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Structure Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822).
Domain Th
Target Relevance information above includes information from UniProt accession: P78504
The UniProt Consortium

Data

SDS-PAGE gel of Human Jagged 1/JAG1 Protein

Human Jagged 1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.