SDS-PAGE gel of Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) ?Heterodime 2421

Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein 2421

$375.00 – $1,250.00

Summary

Expression: HEK293
Pure: Yes (SDS-PAGE)
Amino Acid Range: Phe39-Leu1012(ITGA8) acidic tail & Gln21-Asp728(ITGB1) basic tail

available size

Clear

SKU: 2421parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P53708(ITGA8)&P05556(ITGB1)
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	Human Integrin alpha 8 beta 1 is a heterodimeric glycoprotein composed of integrin alpha 8 and integrin beta 1 that mainly expressed in smooth muscle cells. It functions as a receptor for Tenascin, Fibronectin, and Vitronectin and can promote attachment, cell spreading, and neurite outgrowth.
molecular weight	The protein has a predicted MW of 113.90 kDa (ITGA8) & 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 120-140 kDa (ITGA8) and 100-120 kDa (ITGB1) based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein 2421

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Human Integrin alpha 8 beta 1 is a heterodimeric glycoprotein composed of integrin alpha 8 and integrin beta 1 that mainly expressed in smooth muscle cells. It functions as a receptor for Tenascin, Fibronectin, and Vitronectin and can promote attachment, cell spreading, and neurite outgrowth.
Protein names Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Gene names ITGA8,ITGA8
Protein family Integrin alpha chain family
Mass 117474Da
Function Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Subellular location Membrane ; Single-pass type I membrane protein. Cell membrane .
Tissues Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Structure Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.
Target Relevance information above includes information from UniProt accession: P53708
The UniProt Consortium

Data

SDS-PAGE gel of Human Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodime

Human ITGA8&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.