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Human IL-13Ra2 Protein 4565

$210.00$700.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Asp27-Leu342
SKU: 4565parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q14627

express system

HEK293

product tag

C-hFc

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2.

molecular weight

The protein has a predicted MW of 63.7 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human IL-13Ra2 Protein 4565

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha ', is now referred to as IL-13 R alpha 2.
Protein names
Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)
Gene names
IL13RA2,IL13RA2 IL13R
Protein family
Type I cytokine receptor family, Type 5 subfamily
Mass
9606Da
Function
FUNCTION: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). {ECO:0000269|PubMed:20223216}.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Domain
DOMAIN: Th
Target Relevance information above includes information from UniProt accession : Q14627
The UniProt Consortium

Data

ELISA with Human IL-13Ra2 Protein
Immobilized Human IL-13, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human IL-13Ra2, hFc Tag with the EC50 of 1.0µg/ml determined by ELISA.
HPLC of Human IL-13Ra2 Protein
The purity of Human IL-13Ra2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human IL-13Ra2 Protein
Human IL-13Ra2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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