Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein 3051

$310.00 – $1,125.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gly25-Thr305(HLA-A*01:01), Ile21-Met119(B2M)and YTDNWLAVY peptide.

available size

Clear

SKU: 3051parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q5SUL5(HLA-A*01:01)&P61769(B2M)&YTDNWLAVY
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic features of the tumor. Inhibition of DSG3 significantly suppresses carcinogenic potential in cellular and in vivo animal studies. These findings suggest that DSG3 is a potential molecular target in the development of adjuvant therapy for HNC.
molecular weight	The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein 3051

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic features of the tumor. Inhibition of DSG3 significantly suppresses carcinogenic potential in cellular and in vivo animal studies. These findings suggest that DSG3 is a potential molecular target in the development of adjuvant therapy for HNC.
Protein names HLA class I histocompatibility antigen A alpha chain (MHC class I antigen) (Major histocompatibility complex, class I, A)
Gene names HLA-A,HLA-A
Protein family MHC class I family
Mass 40846Da
Target Relevance information above includes information from UniProt accession: Q5SUL5
The UniProt Consortium

Data

HPLC of Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein

The purity of Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein

Human HLA-A*01:01&B2M&DSG3 (YTDNWLAVY) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.