Human FOLR2 Protein 3584

$150.00 – $500.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Thr17-Met228

SKU: 3584parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P14207
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).
molecular weight	The protein has a predicted MW of 25.5 kDa. Due to glycosylation, the protein migrates to 30-38 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human FOLR2 Protein 3584

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
FOLR1 and FOLR2 are equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from epithelia with or without a micelle-encapsulated GPI-anchor into milk and other body fluids/secretions, e.g. semen where its interaction with spermatozoa indicates a role in male fertility. FOLR1 and FOLR2 serve as serum biomarkers of various diseases. FOLR3 possesses no GPI-anchor and originates from secretory granules of neutrophil granulocytes; its concentration in serum correlates to the FOLR3 content in leukocytes and rises with increased leukocyte counts (infection, malignancy and pregnancy).
Protein names
Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)
Gene names
FOLR2,FOLR2
Protein family
Folate receptor family
Mass
9606Da
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Catalytic activity
BINDING 97; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0007744|PDB:4KMZ"; BINDING 101; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0007744|PDB:4KMZ"; BINDING 118..122; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0007744|PDB:4KMZ"; BINDING 151..156; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0007744|PDB:4KMZ"; BINDING 190; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0007744|PDB:4KMZ"
Subellular location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted .
Tissues
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Post-translational modification
N-glycosylated.
Target Relevance information above includes information from UniProt accession: P14207
The UniProt Consortium

Data

Immobilized Human FOLR2, His Tag at 0.2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-FOLR2 Antibody, hFc Tag with the EC50 of 4.1ng/ml determined by ELISA.

The purity of Human FOLR2 is greater than 95% as determined by SEC-HPLC.

Human FOLR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.