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Human FGL1 Protein 4406

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Asp64-Asn305
SKU: 4406parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q08830

express system

HEK293

product tag

N-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII.Fibrinogen-like Protein 1 is a major immune.

molecular weight

The protein has a predicted MW of 31.9 kDa same as Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human FGL1 Protein 4406

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII.Fibrinogen-like Protein 1 is a major immune.
Protein names
Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
Gene names
FGL1,FGL1 HFREP1
Mass
9606Da
Function
FUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:19880967, ECO:0000269|PubMed:30580966}.
Subellular location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:30580966}. Note=Secreted in the blood plasma. {ECO:0000269|PubMed:30580966}.
Tissues
TISSUE SPECIFICITY: Under normal conditions, liver-specific. {ECO:0000269|PubMed:11470158}.
Structure
SUBUNIT: Homodimer (PubMed:11470158). Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2) (PubMed:30580966). {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:30580966}.
Target Relevance information above includes information from UniProt accession : Q08830
The UniProt Consortium

Data

ELISA with Human FGL1 Protein
Immobilized Human FGL1, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human LAG3, hFc Tag with the EC50 of 75.1ng/ml determined by ELISA.
HPLC of Human FGL1 Protein
The purity of Human FGL1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human FGL1 Protein
Human FGL1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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