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Human FGF10 Protein 4705

$240.00$800.00

Summary

  • Expression: E.coli
  • Binding assay: Yes (SPR)
  • Amino Acid Range: Gln38-Ser208
SKU: 4705parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O15520

express system

E.coli

product tag

No Tag

purity

> 90% as determined by Tris-Bis PAGE

background

Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more susceptible to chronic disease.

molecular weight

The protein has a predicted MW of 19.3 kDa. The protein migrates to 25 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 0.1EU per μg by the LAL method.

Human FGF10 Protein 4705

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more susceptible to chronic disease.
Protein names
Fibroblast growth factor 10 (FGF-10) (Keratinocyte growth factor 2)
Gene names
FGF10,FGF10
Protein family
Heparin-binding growth factors family
Mass
9606Da
Function
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}.
Subellular location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Structure
SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. {ECO:0000269|PubMed:12591959, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:16597617}.
Target Relevance information above includes information from UniProt accession : O15520
The UniProt Consortium

Data

SPR with Human FGF10 Protein
Human FGF10, No Tag immobilized on CM5 Chip can bind Human FGFR2 beta (IIIb) , hFc Tag with an affinity constant of 0.299 nM as determined in SPR assay (Biacore T200).
SDS-PAGE gel of Human FGF10 Protein
Human FGF10 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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