Human DLL3 Protein 4442

$300.00 – $1,000.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Ala27-Arg490

SKU: 4442parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9NYJ7
express system	HEK293
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE
background	Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
molecular weight	The protein has a predicted MW of 50.4 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1 EU per μg by the LAL method.

Human DLL3 Protein 4442

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Protein names Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)
Gene names DLL3,DLL3
Mass 9606Da
Function Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Subellular location Membrane ; Single-pass type I membrane protein .
Structure Can bind and activate Notch-1 or another Notch receptor.
Post-translational modification Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
Domain Th
Target Relevance information above includes information from UniProt accession: Q9NYJ7
The UniProt Consortium

Data

Anti-DLL3 Antibody captured on CM5 Chip via Protein A can bind Human DLL3, His Tag with an affinity constant of 0.22 nM as determined in SPR assay (Biacore T200).

Immobilized Human DLL3, His Tag at 0.1 µg/ml (100 µl/Well). Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 4.5 ng/ml determined by ELISA (QC Test).

Human DLL3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.