Human Coagulation Factor III/Tissue Factor Protein 2997

$270.00 – $900.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Ser33-Glu251

available size

Clear

SKU: 2997parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P13726
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer.
molecular weight	The protein has a predicted MW of 25.89 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Coagulation Factor III/Tissue Factor Protein 2997

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer.
Protein names Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Gene names F3,F3
Protein family Tissue factor family
Mass 9606Da
Function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Catalytic activity #N/A
Subellular location [Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Tissues Lung, placenta and pancreas.
Structure Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
Target Relevance information above includes information from UniProt accession: P13726
The UniProt Consortium

Data

ELISA with Human Coagulation Factor III/Tissue Factor Protein

Immobilized Human Coagulation Factor III, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-Coagulation Factor III Antibody, hFc Tag with the EC50 of 4.9ng/ml determined by ELISA.

HPLC of Human Coagulation Factor III/Tissue Factor Protein

The purity of Human Coagulation Factor III is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human Coagulation Factor III/Tissue Factor Protein

Human Coagulation Factor III on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.