Human CLEC10A Protein 3612

$270.00 – $900.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gln61-Ser316

SKU: 3612parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q8IUN9
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CLEC10A, (C-type lectin domain family 10, member A), as the member of C-type lectin receptors (CLRs), plays a vital role in modulating innate immunity and adaptive immunity and has shown great potential as an immunotherapy target for cancers. However, there is no functional research of CLEC10A in prognostic risk, immunotherapy or any other treatment of lung adenocarcinoma (LUAD).
molecular weight	The protein has a predicted MW of 29.7 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CLEC10A Protein 3612

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CLEC10A, (C-type lectin domain family 10, member A), as the member of C-type lectin receptors (CLRs), plays a vital role in modulating innate immunity and adaptive immunity and has shown great potential as an immunotherapy target for cancers. However, there is no functional research of CLEC10A in prognostic risk, immunotherapy or any other treatment of lung adenocarcinoma (LUAD).
Protein names C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (DC-asialoglycoprotein receptor) (DC-ASGPR) (Macrophage galactose-type lectin) (MGL) (Macrophage lectin 2) (CD antigen CD301)
Gene names CLEC10A,CLEC10A CLECSF13 CLECSF14 HML
Mass 35446Da
Function FUNCTION: C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides (PubMed:15802303, PubMed:23507963). Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions (PubMed:15802303, PubMed:16998493, PubMed:22213806). Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively (PubMed:15802303, PubMed:17616966, PubMed:17804752). {ECO:0000269\|PubMed:15802303, ECO:0000269\|PubMed:16998493, ECO:0000269\|PubMed:17616966, ECO:0000269\|PubMed:17804752, ECO:0000269\|PubMed:22213806, ECO:0000269\|PubMed:23507963, ECO:0000269\|PubMed:33724805, ECO:0000269\|PubMed:8598452}.
Subellular location SUBCELLULAR LOCATION: Cell membrane {ECO:0000269\|PubMed:16998493, ECO:0000269\|PubMed:17616966, ECO:0000269\|PubMed:17804752}; Single-pass type II membrane protein. Early endosome membrane {ECO:0000269\|PubMed:17616966}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000269\|PubMed:17616966}; Single-pass type II membrane protein. Note=Recycles between the plasma membrane and the endolysosomal compartment. Upon antigen binding, internalizes via endocytosis and then dissociates from antigen at acidic pH characteristic of endolysosomal vesicles. {ECO:0000269\|PubMed:17616966}.
Tissues TISSUE SPECIFICITY: Expressed in myeloid antigen presenting cells in lymph nodes and skin (at protein level). Expressed in dermal dendritic cells (at protein level). {ECO:0000269\|PubMed:16998493, ECO:0000269\|PubMed:22213806}.
Structure SUBUNIT: Interacts with A-, B- and C-domain containing PTPRC/CD45 isoforms: isoform 1/CD45ABC, isoform 3/CD45AB, isoform 5/CD45BC and isoform 7/CD45B. Does not interact with PTPRC/CD45 isoform 2/CD45RO, a memory T cell marker. {ECO:0000269\|PubMed:16998493}.
Target Relevance information above includes information from UniProt accession: Q8IUN9
The UniProt Consortium

Data

The purity of Human CLEC10A is greater than 95% as determined by SEC-HPLC.

Human CLEC10A on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.