Human Claudin 9 Protein-VLP 3504

$1,100.00 – $3,800.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Met1-Val217

SKU: 3504parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O95484
express system	HEK293
product tag
purity	> 95% as determined by HPLC
background	Claudins (CLDNs) are tetraspan proteins with a short cytoplasmic N‑terminus, two extracellular loops and a C‑terminal cytoplasmic domain. They function as a physical barrier or gate of small molecules and as signaling platforms to coordinate diverse cellular behaviors. CLDNs are useful cancer biomarkers, as they are frequently upregulated and are associated with malignant traits of cancers, such as invasion, migration, metastasis and chemoresistance. Claudin‑9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types.
molecular weight	The target protein has a predicted MW of 24.1 kDa.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Claudin 9 Protein-VLP 3504

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Claudins (CLDNs) are tetraspan proteins with a short cytoplasmic N-terminus, two extracellular loops and a C-terminal cytoplasmic domain. They function as a physical barrier or gate of small molecules and as signaling platforms to coordinate diverse cellular behaviors. CLDNs are useful cancer biomarkers, as they are frequently upregulated and are associated with malignant traits of cancers, such as invasion, migration, metastasis and chemoresistance. Claudin-9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types.
Protein names Claudin-9
Gene names CLDN9,CLDN9
Protein family Claudin family
Mass 9606Da
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Subellular location Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
Tissues Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Structure Interacts with CLDN1, CD81 and OCLN (PubMed:20375010).
Target Relevance information above includes information from UniProt accession: O95484
The UniProt Consortium

Data

Immobilized Human Claudin 9 VLP at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-Claudin 9 Antibody, hFc Tag with the EC50 of 1.8ng/ml determined by ELISA.

The purity of Human Claudin 9 VLP is greater than 95% as determined by SEC-HPLC.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.