Human CKAP4 Protein 2603

$1,050.00

Summary

Expression: E.coli
Pure: Yes (HPLC)
Amino Acid Range: His128-Val602

SKU: 2603parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q07065
express system	E.coli
product tag	N-His
purity	> 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor at the cell surface.
molecular weight	The protein has a predicted MW of 53.66 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CKAP4 Protein 2603

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor at the cell surface.
Protein names Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)
Gene names CKAP4,CKAP4
Mass 9606Da
Function Mediates the anchoring of the endoplasmic reticulum to microtubules.; High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Subellular location Endoplasmic reticulum membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation.
Structure Interacts with REEP5.
Post-translational modification Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling (PubMed:19144824).; Increased phosphorylation during mitosis prevents binding to microtubules.
Target Relevance information above includes information from UniProt accession: Q07065
The UniProt Consortium

Data

The purity of Human CKAP4 Protein is greater than 90% as determined by SEC-HPLC.

Human CKAP4 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.