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Human CD200/OX-2 Protein 5214

$195.00$650.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln31-Gly232
SKU: 5214parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P41217

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.

molecular weight

The protein has a predicted MW of 23.5 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human CD200/OX-2 Protein 5214

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.
Protein names
OX-2 membrane glycoprotein (CD antigen CD200)
Gene names
CD200,CD200 MOX1 MOX2 My033
Mass
9606Da
Function
FUNCTION: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subellular location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Structure
SUBUNIT: CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.
Target Relevance information above includes information from UniProt accession : P41217
The UniProt Consortium

Data

ELISA with Human CD200/OX-2 Protein
Immobilized Human CD200, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human CD200 R1, hFc Tag with the EC50 2.4ng/ml determined by ELISA.
HPLC of Human CD200/OX-2 Protein
The purity of Human CD200 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human CD200/OX-2 Protein
Human CD200 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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