Human CCL11 Protein 3005

$300.00 – $1,000.00

Summary

Expression: E.coli
Pure: Yes (HPLC)
Amino Acid Range: Gly24-Pro97

SKU: 3005parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P51671
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders.
molecular weight	The protein has a predicted MW of 9.46 kDa. The protein migrates to 13-15 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CCL11 Protein 3005

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders.
Protein names Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
Gene names CCL11,CCL11 SCYA11
Protein family Intercrine beta (chemokine CC) family
Mass 10732Da
Function FUNCTION: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956). Binds to CCR3 (PubMed:8631813). {ECO:0000269\|PubMed:8597956, ECO:0000269\|PubMed:8631813}.
Subellular location SUBCELLULAR LOCATION: Secreted {ECO:0000305\|PubMed:8597956}.
Post-translational modification PTM: O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues. {ECO:0000269\|PubMed:9578468}.
Target Relevance information above includes information from UniProt accession: P51671
The UniProt Consortium

Data

The purity of Human CCL11 is greater than 90% as determined by SEC-HPLC.

Human CCL11 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.