ELISA with Human BCMA/TNFRSF17 Protein 5199

Human BCMA/TNFRSF17 Protein 5199

$300.00 – $1,000.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Met1-Ala54

SKU: 5199parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q02223
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
molecular weight	The protein has a predicted MW of 8.9 kDa. Due to glycosylation, the protein migrates to 12 kDa and 15-17 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human BCMA/TNFRSF17 Protein 5199

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
Protein names Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Gene names TNFRSF17,TNFRSF17 BCM BCMA
Mass 20165Da
Function Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Subellular location Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Tissues Expressed in mature B-cells, but not in T-cells or monocytes.
Structure Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
Domain TOPO_DOM 1
Target Relevance information above includes information from UniProt accession: Q02223
The UniProt Consortium

Data

Immobilized Human BCMA, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-BCMA Antibody, hFc Tag with the EC50 of 2.4ng/ml determined by ELISA (QC Test).

Immobilized Human BCMA, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human BAFF, His Tag with the EC50 of 7.1ng/ml determined by ELISA.

The purity of Human BCMA is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human BCMA/TNFRSF17 Protein

Human BCMA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.