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Human BCMA/TNFRSF17 Protein 4419

$240.00$800.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Met1-Ala54
SKU: 4419parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q02223

express system

HEK293

product tag

C-hFc

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).

molecular weight

The protein has a predicted MW of 31.4 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human BCMA/TNFRSF17 Protein 4419

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
Protein names
Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
Gene names
TNFRSF17,TNFRSF17 BCM BCMA
Mass
20165Da
Function
FUNCTION: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Tissues
TISSUE SPECIFICITY: Expressed in mature B-cells, but not in T-cells or monocytes.
Structure
SUBUNIT: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. {ECO:0000269|PubMed:12721620, ECO:0000269|PubMed:15542592}.
Domain
TOPO_DOM 1
Target Relevance information above includes information from UniProt accession : Q02223
The UniProt Consortium

Data

ELISA with Human BCMA/TNFRSF17 Protein
Immobilized Human APRIL Trimer, His Tag at 0.2µg/ml (100µl/Well) on the plate. Dose response curve for Human BCMA, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA.
HPLC of Human BCMA/TNFRSF17 Protein
The purity of Human BCMA is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human BCMA/TNFRSF17 Protein
Human BCMA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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