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Human ANGPTL7/CDT6 Protein 4597

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: GIn27-Pro346
SKU: 4597parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O43827

express system

HEK293

product tag

C-His-Avi

purity

> 90% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha.

molecular weight

The protein has a predicted MW of 40.2 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human ANGPTL7/CDT6 Protein 4597

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha.
Protein names
Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein)
Gene names
ANGPTL7,ANGPTL7 CDT6 UNQ313/PRO356
Mass
9606Da
Function
FUNCTION: Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036). {ECO:0000269|PubMed:21199193, ECO:0000269|PubMed:25622036}.
Subellular location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11682471}.
Tissues
TISSUE SPECIFICITY: Highly expressed in the cornea (at protein level) (PubMed:11682471). Expression is restricted to the stromal layer (PubMed:11682471). Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera (PubMed:11682471). {ECO:0000269|PubMed:11682471, ECO:0000269|PubMed:9727400}.
Structure
SUBUNIT: Homotetramer; disulfide-linked. {ECO:0000269|PubMed:11682471}.
Target Relevance information above includes information from UniProt accession : O43827
The UniProt Consortium

Data

HPLC of Human ANGPTL7/CDT6 Protein
The purity of Human ANGPTL7 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human ANGPTL7/CDT6 Protein
Human ANGPTL7 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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